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For that reason, it really is conceivable which the JIP1/three → ASK1 → MKK4 signaling module may function a conduit to activate JNK when endosomal trafficking is disrupted and glucose stages slide in the early phases of methuosis. Our locating that MKK4 was robustly activated by the methuosis-inducing IPPs, MOMIPP and 2q, and fewer so